Two cases of intestinal spirochetosis in two children are reported. Th
e first patient, a 7 1/2-year-old boy, presented with diarrhea and rec
tal bleeding. After the diagnosis was made by a rectal biopsy, he was
given metronidazole and neomycin. Symptoms persisted despite a further
rectal biopsy that showed clearance of the organisms. Appendiceal spi
rochetosis was an incidental finding in our second patient, an 8-year-
old girl who presented with acute abdominal pain and in whom mesenteri
c adenitis was diagnosed clinically at laparotomy. The possible pathog
enic mechanisms causing clinical symptoms are discussed.