Mdf. Degatta et al., INDIVIDUALIZING VANCOMYCIN DOSING REGIMENS - AN EVALUATION OF 2 PHARMACOKINETIC DOSING PROGRAMS IN CRITICALLY ILL PATIENTS, Pharmacotherapy, 14(2), 1994, pp. 196-201
We evaluated the predictive performance of two commercial computer pro
grams (Abbott and Simkin) for pharmacokinetic dosing of vancomycin in
50 critically ill patients, 40 with hematologic malignancies and 10 in
intensive care. Predictive performance was assessed for both pharmaco
kinetics and forecasting vancomycin serum levels by using a set of pea
k and trough drug levels per patient. The effect of renal function and
serum sampling (steady state, nonsteady state) on predictive performa
nce of both programs was also analyzed. No statistically significant d
ifferences were found between the programs for predicting either pharm
acokinetics or serum levels, regardless of a patient's renal function
or serum sampling. The Abbott and Simkin programs were similar for ind
ividualizing vancomycin dosage regimens.