CYTOMEGALOVIRUS COLITIS AFTER 5-FLUOROURACIL AND INTERFERON-ALPHA THERAPY

Cytomegalovirus (CMV) infection is an opportunistic viral infection pr imarily affecting immunocompromised patients. Patients with inflammato ry bowel disease have an increased risk for developing CMV infections of the gastrointestinal tract. While receiving continuous infusion of 5-fluorouracil and interferon-alpha, a 72-year-old woman with stage IV pancreatic carcinoma developed severe colitis with diarrhea that was refractory to conventional antidiarrheals. A biopsy specimen from the colon revealed CMV inclusions, which were confirmed by immunofluoresce nce. The patient was given ganciclovir 210 mg (5 mg/kg) every 12 hours for 14 days, and the diarrhea resolved after approximately 8 days of therapy. This is the first reported case of CMV colitis associated wit h combination 5-fluorouracil and interferon-alpha therapy.