Objective: To estimate the number of episodes of intravascular cathete
r associated sepsis that occur in Australia per year. Design and setti
ng: Data were collected from 15 Australian hospitals (mainly tertiary
referral hospitals). Ah positive results of blood cultures were follow
ed up and the primary sepsis site identified and recorded. The average
study period was 1.2 years. Results: Eight hundred and nine episodes
of systemic sepsis associated with intravascular catheters were identi
fied from 4957 separate episodes of bacteraemia or fungaemia. Of those
in which the catheter site was known, there were 491 episodes of seps
is associated with central vein catheters and 233 with peripheral vein
catheters. Systemic sepsis with peripheral vein catheters occurred wi
th 0.36 of every 1000 catheters purchased, but with central vein cathe
ters it was 23 episodes per 1000 catheters (relative risk, 64; 95% con
fidence interval, 54-76). In these hospitals, 8.2 episodes of intravas
cular catheter associated sepsis occurred annually per 100 beds and 1.
5 episodes per 1000 admissions. From these figures, at least 3000 case
s of intravascular sepsis may occur per year in Australia. Conclusions
: Intravascular catheter sepsis is common. Central vein catheters caus
e more sepsis than peripheral vein catheters. With the greater use of
catheters this problem is likely to increase.