SEQUENCE OF A SEGMENT OF YEAST CHROMOSOME-II SHOWS 2 NOVEL GENES, ONEALMOST ENTIRELY HYDROPHOBIC AND THE OTHER EXTREMELY ASPARAGINE-SERINERICH

A 3.2 kb EcoRI fragment of yeast Saccharomyces cerevisiae was entirely sequenced. Two new open reading frames were identified. The first is extremely hydrophobic, and would likely be an integral membrane protei n. It has significant similarity to only one reported gene, a gene of unknown function from Drosophila melanogaster. The second ORF is aspar agine-rich and very serine-rich, with a remarkable stretch of nearly 2 6 consecutive asparagine residues comprised of the same codon. It has no significant similarity to any reported gene. The fragment maps to c hromosome II on the left arm between the CDC27 and ILS1 loci. The nucl eotide sequence reported in this paper has been deposited in the GenBa nk database with the Accession Number M89908.