STUDIES ON THE INTRINSIC ACTIVITY (EFFICACY) OF HUMAN ADRENERGIC-RECEPTORS - COEXPRESSION OF BETA(1) AND BETA(2) REVEALS A LOWER EFFICACY FOR THE BETA(1) RECEPTOR

Authors
BIRNBAUMER L LEVY FO ZHU X KAUMANN AJ
Citation
L. Birnbaumer et al., STUDIES ON THE INTRINSIC ACTIVITY (EFFICACY) OF HUMAN ADRENERGIC-RECEPTORS - COEXPRESSION OF BETA(1) AND BETA(2) REVEALS A LOWER EFFICACY FOR THE BETA(1) RECEPTOR, Texas Heart Institute journal, 21(1), 1994, pp. 16-21
Citations number
NO
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
Texas Heart Institute journal → ACNP
ISSN journal
07302347
Volume
21
Issue
1
Year of publication
1994
Pages
16 - 21
Database
ISI
SICI code
0730-2347(1994)21:1<16:SOTIA(>2.0.ZU;2-K
Abstract
Through co-expression of the human beta1 and beta2 adrenergic receptor s in a single tester cell (the murine L fibroblast) and through assayi ng the effect of the beta1 and beta2 selective blockers CGP 20712A and ICI 118551 on isoproterenol-stimulated adenylyl cyclase, it is shown that the maximal stimulation achievable with a given cell density of b eta1 adrenergic receptor is less than that obtained with the same dens ity of the beta2 adrenergic receptor It is concluded that the efficacy of the 2 receptors differs in that the beta1 adrenergic receptor has a lower efficacy (or intrinsic activity) than does the beta2 adrenergi c receptor.