RECENT ADVANCES IN LIPOPROTEIN AND ATHEROSCLEROSIS RESEARCH AT BAYLORCOLLEGE OF MEDICINE - APOLIPOPROTEIN-B, LIPOPROTEIN[A], AND TRANSPLANTATION ARTERIOPATHY
Cm. Ballantyne et al., RECENT ADVANCES IN LIPOPROTEIN AND ATHEROSCLEROSIS RESEARCH AT BAYLORCOLLEGE OF MEDICINE - APOLIPOPROTEIN-B, LIPOPROTEIN[A], AND TRANSPLANTATION ARTERIOPATHY, Texas Heart Institute journal, 21(1), 1994, pp. 48-55
A multidisciplinary team approach with focused objectives characterize
s research at Baylor College of Medicine into the causes, prevention,
and treatment of atherosclerotic disease. Current clinical activities
range from programs to modify lifestyle for the primary prevention of
coronary artery disease to a large, angiographically monitored lipid-l
owering trial. In basic research, much attention has been focused on t
he plasma lipoproteins and their roles in atherogenesis. The current r
eview highlights recent advances in ongoing basic research involving 1
) apolipoprotein (apo) B, whose form apo B-100 serves as a ligand for
the low-density lipoprotein receptor; 2) lipoprotein[a], elevated plas
ma levels of which are predictive of atherosclerotic disease; and 3) t
ransplantation arteriopathy, which impedes long-term survival of cardi
ac transplant recipients.