A 10-year-old speyed female cat was referred because of a blue-grey cu
taneous nodule on its cheek ventromedial to the right eye, and a nasal
squamous cell carcinoma. The blue-grey lesion was surgically excised,
and the nasal carcinoma treated cryosurgically using liquid nitrogen.
Histological and mycological investigations demonstrated the pigmente
d lesion to be a phaeohyphomycotic granuloma caused by Exophiala jeans
elmei. Fluconazole and subsequently ketoconazole were administered to
prevent recurrence of the infection. The presence of a pigmented nodul
e or plaque in the periocular or nasal region should be considered sug
gestive of infection with a dematiaceous fungus.