SOLUTION-PHASE SYNTHESIS OF DITHYMIDINE PHOSPHORODITHIOATE USING NEW S-PROTECTING GROUPS IN COMBINATION WITH A CHEMOSELECTIVE COUPLING REAGENT (PYNOP)

Authors
KEHLER J PUSCHL A DAHL O
Citation
J. Kehler et al., SOLUTION-PHASE SYNTHESIS OF DITHYMIDINE PHOSPHORODITHIOATE USING NEW S-PROTECTING GROUPS IN COMBINATION WITH A CHEMOSELECTIVE COUPLING REAGENT (PYNOP), Nucleosides & nucleotides, 16(1-2), 1997, pp. 23-32
Citations number
25
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
1-2
Year of publication
1997
Pages
23 - 32
Database
ISI
SICI code
0732-8311(1997)16:1-2<23:SSODPU>2.0.ZU;2-M
Abstract
A method for the synthesis of O-thymidin-3'-yl S-alkyl dithiophosphate monomers 1 with different S-protecting groups has been developed. The se for solution phase synthesis of dithymidine phosphorodithioate by a new method. Coupling reactions are fast (15 min.) and the products ph osphorothioate contaminations.