SYNTHESIS AND ANTIVIRAL EVALUATION OF N-BETA-D-RIBOSIDES OF ERGOT ALKALOIDS

Authors
KREN V PISKALA A SEDMERA P HAVLICEK V PRIKRYLOVA V WITVROUW M DECLERCQ E
Citation
V. Kren et al., SYNTHESIS AND ANTIVIRAL EVALUATION OF N-BETA-D-RIBOSIDES OF ERGOT ALKALOIDS, Nucleosides & nucleotides, 16(1-2), 1997, pp. 97-106
Citations number
17
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
1-2
Year of publication
1997
Pages
97 - 106
Database
ISI
SICI code
0732-8311(1997)16:1-2<97:SAAEON>2.0.ZU;2-A
Abstract
N-beta-D-Ribosides of agroclavine (1), elymoclavine (2), lysergene (4) , lysergol (3), and 9,10-dihydrolysergol (5) were prepared by SnCl2 ca talyzed ribosylation of their TMS derivatives with -O-acetyl-2,3,5-tri -O-benzoyl-beta-D-ribofuranose. None of the new compounds exhibited ac tivity against HIV or other viruses tested.