SYNTHESIS AND ANTIVIRAL AND CYTOSTATIC ACTIVITIES OF CARBOCYCLIC NUCLEOSIDES INCORPORATING A MODIFIED CYCLOPENTANE RING .1. GUANOSINE ANALOGS

Authors
BLANCO JM CAAMANO O FERNANDEZ F GOMEZ G NIETO MI BALZARINI J PADALKO E DECLERCQ E
Citation
Jm. Blanco et al., SYNTHESIS AND ANTIVIRAL AND CYTOSTATIC ACTIVITIES OF CARBOCYCLIC NUCLEOSIDES INCORPORATING A MODIFIED CYCLOPENTANE RING .1. GUANOSINE ANALOGS, Nucleosides & nucleotides, 16(1-2), 1997, pp. 159-171
Citations number
9
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
1-2
Year of publication
1997
Pages
159 - 171
Database
ISI
SICI code
0732-8311(1997)16:1-2<159:SAAACA>2.0.ZU;2-V
Abstract
Six new carbocyclic nucleosides were prepared by constructing a guanin e (compounds 6, 8 and 10) or 8-azaguanine (compounds 7, 9 and 11) base on the amino group of (1R, 3-(aminomethyl)-1,2,2-trimethylcyclopentyl methanol (2), and their activities against 13 viruses and 3 tumor cell lines were determined. Compounds 9, 10 and 11 showed activity against human immunodeficiency virus type 1 (HIV-1), and compound 11 also aga inst vaccina virus, whereas compounds 6 and 7 showed some inhibition o f tumor cell proliferation.