INFLUENCE OF TOLFENAMIC ACID ON AIRWAY CONTRACTILITY IN GUINEA-PIGS

The effect of the NSAIDs tolfenamic acid and indomethacin was tested o n acetylcholine-induced and antigen-induced contractions in guinea pig airways. Indomethacin potentiated antigen-induced contractions while tolfenamic acid showed dilatory properties. The effect of the drugs on acetylcholine-induced contractions showed no significant differences; indomethacin had a slightly increasing tendency while tolfenamic acid reduced the contractile response. These results indicate that tolfena mic acid does not have bronchoconstrictive properties, which is a comm on side effect of other NSAIDs in asthmatics.