The Okamoto-Nolen-Schiffer anomaly, i.c. the failure theory to explain
the difference of masses of mirror nuclei [1] provides the well known
challenge to traditional nuclear physics, yielding the build up of is
ospin breaking forces. Here we show how certain features of such force
s can be obtained from QCD sum rules analyses. This problem is only a
single example of the broad class of problems arising in investigation
of the nucleon placed into the matter for which the approach is neede
d.