DONOR B-CELL LYMPHOMA OF THE BRAIN AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR ACUTE MYELOID-LEUKEMIA

We present a case of EBV-induced cerebral B cell lymphoproliferation o f donor origin after HLA-matched allogeneic BMT for AML. The presentat ion was noteworthy as this 4-year-old girl was grafted after a conditi oning regimen without irradiation, with an unmanipulated, HLA-matched graft. Furthermore, the cerebral mass developed long after reduction o f immunosuppressive therapy following improvement of severe GVHD. To o ur knowledge, such cerebral lymphoproliferation, under these transplan t conditions, has never been described.