THE PENETRATION OF TOPICAL CYSTEAMINE INTO THE HUMAN EYE

The penetration of cysteamine into human aqueous was measured to asses s its suitability as a topical agent for the prevention of radiation-i nduced cataract. Cysteamine drops (0.5% and 1.0%) were administered pr eoperatively to cataract patients every half hour, for two, four, six or eight hours. Aqueous humor was collected at the start of surgery an d assayed for total free thiol. There was no significant difference in the aqueous thiol level of any of the treatment groups compared with the controls. No side effects were observed.