PEPSIN-CATALYZED SYNTHESIS OF PEPTIDES IN ORGANIC-SOLVENTS

Authors
ANISIMOVA VV LYSOGORSKAYA EN FILIPPOVA IY OKSENOIT ES STEPANOV VM
Citation
Vv. Anisimova et al., PEPSIN-CATALYZED SYNTHESIS OF PEPTIDES IN ORGANIC-SOLVENTS, Bioorganiceskaa himia, 20(3), 1994, pp. 316-322
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
20
Issue
3
Year of publication
1994
Pages
316 - 322
Database
ISI
SICI code
0132-3423(1994)20:3<316:PSOPIO>2.0.ZU;2-X
Abstract
The porcine pepsin immobilized on inorganic supports catalyzes the pep tide bond formation in organic solvents. Dependence of the peptide bon d formation between Z-Ala-Ala-Phe-OH and H-Leu-Ala-Ala-OCH3 upon the p orous material, organic solvent, reaction time, enzyme concentration, ionic strength and pH was studied. Syntheses of peptides of the genera l formula Z-Ala-Ala-Xaa-Yaa-Ala-Ala-OCH3, where Xaa - Phe, Tyr, Trp; Y aa = Leu, Phe, Tyr, Trp, were carried out.