TRYPANOSOMA-CRUZI STOCKS ISOLATED FROM ACUTE CHAGAS-DISEASE PATIENTS LEAD TO LETHAL MURINE INFECTION

Authors
OLIVEIRA EC STEFANI MMA CAMPOS DE ANDRADE ALSS SILVA SA RASSI A LUQUETTI AO
Citation
Ec. Oliveira et al., TRYPANOSOMA-CRUZI STOCKS ISOLATED FROM ACUTE CHAGAS-DISEASE PATIENTS LEAD TO LETHAL MURINE INFECTION, Transactions of the Royal Society of Tropical Medicine and Hygiene, 91(1), 1997, pp. 25-27
Citations number
24
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
Journal title
Transactions of the Royal Society of Tropical Medicine and Hygiene → ACNP
ISSN journal
00359203
Volume
91
Issue
1
Year of publication
1997
Pages
25 - 27
Database
ISI
SICI code
0035-9203(1997)91:1<25:TSIFAC>2.0.ZU;2-R
Abstract
Ten Trypanosoma cruzi stocks recently isolated from patients in acute and chronic phases of Chagas disease were inoculated to susceptible (A /Sn) mice. The mice were inoculated with 10(4) trypomastigotes intrape ritoneally and monitored for parasitaemia and mortality for up to 300 d. The results demonstrated that (i) T. cruzi stocks isolated from pat ients in the acute phase killed animals, while stocks from patients in the chronic phase did not; (ii) survival curves differed statisticall y among mice infected with lethal stocks, and (iii) parasite burden di d not affect the mortality rate of mice.