COMPARISON OF THE EMETOGENIC POTENTIAL BETWEEN CISPLATIN AND CARBOPLATIN IN COMBINATION WITH ALKYLATING-AGENTS

Platinum-based polychemotherapy is widely used in the treatment of gyn ecological cancer. Emesis is one of the most disturbing side-effects o f platinum therapy. We performed a study to evaluate and compare the e metogenic potential and the different emesis pattern after cisplatin a nd carboplatin under antiemetic treatment with ondansetron. One hundre d and twenty-two patients with either cisplatin-containing (n = 70) or carboplatin-containing (n = 52) first-line chemotherapy were included . Treatment with cisplatin led more frequently to emesis and patients suffered from more severe emesis than carboplatin treated patients. De layed emesis was observed after both platinum analogues but occurred m ore frequently and lasted longer after cisplatin.