Lmg. Antunes et Cs. Takahashi, CYTOGENETIC EFFECTS OF MEBENDAZOLE ON IN-VIVO AND IN-VITRO MAMMALIAN SYSTEMS, Brazilian journal of genetics, 17(3), 1994, pp. 273-276
Mebendazole (MBZ), (methyl-5 benzoyl benzimidazole-2-carbamate), a pot
ent antihelmintic agent, was tested for clastogenicity in Wistar rat b
one marrow cells (1300, 1750, 3500 and 7000 mg/kg b.w.) and for both c
lastogenicity and antimitotic potential in human peripheral blood lymp
hocytes in culture (5, 10 and 20 mu g/ml culture medium). One-hundred
metaphases/treatment were analyzed for induction of chromosome aberrat
ions and 2000 cells/treatment were counted to determine the mitotic in
dex. MBZ did not induce an increase in the frequency of chromosome abe
rrations, however it was effective in blocking the cell cycle at metap
hase.