MOUSE T-LYMPHOCYTES THAT EXPRESS A GAMMA-DELTA T-CELL ANTIGEN RECEPTOR CONTRIBUTE TO RESISTANCE TO SALMONELLA INFECTION IN-VIVO

Citation
Pf. Mixter et al., MOUSE T-LYMPHOCYTES THAT EXPRESS A GAMMA-DELTA T-CELL ANTIGEN RECEPTOR CONTRIBUTE TO RESISTANCE TO SALMONELLA INFECTION IN-VIVO, Infection and immunity, 62(10), 1994, pp. 4618-4621
Citations number
21
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
ISSN journal
00199567
Volume
62
Issue
10
Year of publication
1994
Pages
4618 - 4621
Database
ISI
SICI code
0019-9567(1994)62:10<4618:MTTEAG>2.0.ZU;2-B
Abstract
Mice depleted of lymphocytes expressing the alpha beta or the gamma de lta T-cell receptor for antigen (TCR) by antibody treatment were infec ted orally with Salmonella enteritidis. In both groups of treated mice , the 50% lethal dose decreased, suggesting that both the alpha beta T CR(+) and the gamma delta TCR(+) subsets contribute to resistance to o ral infection. These data provide further evidence for the contributio n of gamma delta T cells in the response to bacterial infections.