Pf. Mixter et al., MOUSE T-LYMPHOCYTES THAT EXPRESS A GAMMA-DELTA T-CELL ANTIGEN RECEPTOR CONTRIBUTE TO RESISTANCE TO SALMONELLA INFECTION IN-VIVO, Infection and immunity, 62(10), 1994, pp. 4618-4621
Mice depleted of lymphocytes expressing the alpha beta or the gamma de
lta T-cell receptor for antigen (TCR) by antibody treatment were infec
ted orally with Salmonella enteritidis. In both groups of treated mice
, the 50% lethal dose decreased, suggesting that both the alpha beta T
CR(+) and the gamma delta TCR(+) subsets contribute to resistance to o
ral infection. These data provide further evidence for the contributio
n of gamma delta T cells in the response to bacterial infections.