The authors present a case of proved seeding of the pleural space seco
ndary to alcohol ablation of a primary hepatocellular carcinoma. The p
atient underwent alcohol ablation for a 6.5-cm-diameter tumor in the r
ight lobe of the liver; approximately 20 needle punctures were require
d to ensure complete or almost complete destruction of the tumor. Six
months after the original ablation, a hypervascular pleural metastasis
was noted adjacent to the original lesion at computed tomography. Per
cutaneous biopsy of the pleural lesion showed hepatocellular carcinoma
.