POTENT NEW CELL-ADHESION INHIBITORY COMPOUNDS FROM THE ROOT OF TRICHILIA-RUBRA

Authors
MUSZA LL KILLAR LM SPEIGHT P MCELHINEY S BARROW CJ GILLUM AM COOPER R
Citation
Ll. Musza et al., POTENT NEW CELL-ADHESION INHIBITORY COMPOUNDS FROM THE ROOT OF TRICHILIA-RUBRA, Tetrahedron, 50(39), 1994, pp. 11369-11378
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
39
Year of publication
1994
Pages
11369 - 11378
Database
ISI
SICI code
0040-4020(1994)50:39<11369:PNCICF>2.0.ZU;2-Q
Abstract
A series of seco-limonoids, with uncommon hemi ortho ester A-rings, wa s isolated from the root of Trichilia rubra. Their structures were det ermined by extensive spectroscopic studies. The five new and two previ ously known compounds were all found to be potent inhibitors of LFA-1: ICAM-1 mediated cell adhesion.