COPPER-(I) CATALYZED FORMATION OF 3-METHOXY-2,5-DIMETHYLTHIOPHENE AND3,4-DIMETHOXY-2,5-DIMETHYLTHIOPHENE

Authors
PEETERS LD JACOBS SG EEVERS W GEISE HJ
Citation
Ld. Peeters et al., COPPER-(I) CATALYZED FORMATION OF 3-METHOXY-2,5-DIMETHYLTHIOPHENE AND3,4-DIMETHOXY-2,5-DIMETHYLTHIOPHENE, Tetrahedron, 50(39), 1994, pp. 11533-11540
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
39
Year of publication
1994
Pages
11533 - 11540
Database
ISI
SICI code
0040-4020(1994)50:39<11533:CCFO3A>2.0.ZU;2-E
Abstract
3-Methoxy-2,5-dimethylthiophene and 3,4-dimethoxy-2,5-dimethylthiophen e have been prepared from 3,4-dibromo-2,5-dimethylthiophene and sodium methoxide using Cu(I)Br as a catalyst. The influence of some cosolven ts and reaction temperature is investigated. Best results are obtained by refluxing in DMF at 125 degrees C for 4 hours. The mixture is easi ly separated by flash chromatography.