EXTRAGONADAL CHORIOCARCINOMA IN A PATIENT WITH DOWN-SYNDROME

Citation
G. Fountzilas et al., EXTRAGONADAL CHORIOCARCINOMA IN A PATIENT WITH DOWN-SYNDROME, American journal of clinical oncology, 17(5), 1994, pp. 452-455
Citations number
25
Categorie Soggetti
Oncology
ISSN journal
02773732
Volume
17
Issue
5
Year of publication
1994
Pages
452 - 455
Database
ISI
SICI code
0277-3732(1994)17:5<452:ECIAPW>2.0.ZU;2-X
Abstract
There are several reports suggesting that there is a higher incidence of leukemia and testicular cancer in patients with Down syndrome. Fift een patients with Down syndrome and testicular cancer were previously reported. The median age at diagnosis of testicular cancer was 18 year s, (range: 3-45). The histologic subtypes were seminoma in 9 patients, not specified in 2 patients, and 1 patient each of adenocarcinoma, yo lk sac, embryonal, and teratocarcinoma. In this article we describe a case of extragonadal choriocarcinoma in a patient with Down syndrome. To our knowledge, this is the first case ever reported. The patient ha d a complete remission following chemotherapy with cisplatin, etoposid e, and bleomycin and is disease-free with a follow-up of 32 months. Pa tients with Down syndrome and advanced testicular cancer should be tre ated with potentially curative chemotherapy.