THE STREPTOKINASE DOMAIN RESPONSIBLE FOR PLASMINOGEN BINDING

Authors
RODRIGUEZ P FUENTES D MUNOZ E RIVERO D ORTA D ALBURQUERQUE S PEREZ S BESADA V HERRERA L
Citation
P. Rodriguez et al., THE STREPTOKINASE DOMAIN RESPONSIBLE FOR PLASMINOGEN BINDING, Fibrinolysis, 8(5), 1994, pp. 276-285
Citations number
34
Categorie Soggetti
Hematology
Journal title
Fibrinolysis → ACNP
ISSN journal
02689499
Volume
8
Issue
5
Year of publication
1994
Pages
276 - 285
Database
ISI
SICI code
0268-9499(1994)8:5<276:TSDRFP>2.0.ZU;2-7
Abstract
The limited proteolysis of soluble recombinant streptokinase by Sephar ose-immobilized human plasmin(ogen) complexed with recombinant strepto kinase is described. A 17kDa streptokinase fragment comprising residue s Val143 (Glu148) to Arg289 (Lys293) has been shown to be the smallest stable plasminogen binding domain. Moreover, this region seems also t o be important for plasminogen activation.