Sme. Lewis et al., JOUBERT SYNDROME WITH CONGENITAL HEPATIC-FIBROSIS - AN ENTITY IN THE SPECTRUM OF OCULO-ENCEPHALO-HEPATO-RENAL DISORDERS, American journal of medical genetics, 52(4), 1994, pp. 419-426
Joubert syndrome is an autosomal recessive inherited condition charact
erized by agenesis or hypoplasia of the cerebellar vermis, retinal dys
trophy, chorioretinal colobomata, oculomotor abnormalities, episodic h
yperpnea, ataxia, and mental retardation. Congenital hepatic fibrosis
has not previously been described in Joubert syndrome. We report two u
nrelated children with Joubert syndrome and hepatosplenomegaly. On his
topathological examination, both had congenital hepatic fibrosis. Both
were also found to have congenital medullary cystic disease of the ki
dneys. Joubert syndrome appears to be one of a spectrum of congenital
malformation syndromes involving the central nervous system, eye, live
r and kidneys. (C) 1994 Wiley-Liss, Inc.