ENDOLYMPHATIC STROMAL MYOSIS ASSOCIATED WITH TAMOXIFEN USE

A case of low-grade endometrial stromal sarcoma (endolymphatic stromal myosis) occurring in a patient who had received tamoxifen citrate for 3 years following surgical treatment for breast cancer is presented, Endometrial adenocarcinomas have been the most frequently reported tum or associated with tamoxifen use, More recently, uterine sarcomas have also been described in association with the use of tamoxifen, This re port adds only the second case of a low-grade endometrial stromal sarc oma associated with tamoxifen use, As in the first report, the tumor d emonstrated a sex-cord-like pattern of differentiation, an uncommon fe ature of endometrial stromal sarcomas, This suggests a possible associ ation between tamoxifen use and the subsequent development of low-grad e endometrial stromal sarcoma. (C) 1997 Academic Press.