TREATMENT OF STAGE-IV HIGH-GRADE ENDOMETRIAL STROMAL SARCOMA WITH IFOSFAMIDE, ADRIAMYCIN, AND CISPLATIN

A 46-year-old woman with stage IV ''high-grade'' endometrial stromal s arcoma presented with massive uterine bleeding and dyspnea. Her WHO pe rformance status was grade 4. After chemotherapy consisting of ifosfam ide, Adriamycin, and cisplatin, the uterus shrank from 20 x 15 x 15 to 6 x 6 x 8 cm and multiple pulmonary nodules almost completely disappe ared. The PO2 increased from 57.8 to 89.3 mmHg and her performance sta tus improved to grade 0, making it possible for pelvic surgery to be p erformed. At 10 months postoperatively, there was no evidence of disea se. This case suggests that IAP might be effective chemotherapy for pa tients with high-grade endometrial stromal sarcoma. (C) 1997 Academic Press.