TUMOR-SUPPRESSOR GENE-PRODUCTS IN CELL CONTACTS - THE CADHERIN-APC-ARMADILLO CONNECTION

Authors
HULSKEN J BEHRENS J BIRCHMEIER W
Citation
J. Hulsken et al., TUMOR-SUPPRESSOR GENE-PRODUCTS IN CELL CONTACTS - THE CADHERIN-APC-ARMADILLO CONNECTION, Current opinion in cell biology, 6(5), 1994, pp. 711-716
Citations number
48
Categorie Soggetti
Cytology & Histology
Journal title
Current opinion in cell biology → ACNP
ISSN journal
09550674
Volume
6
Issue
5
Year of publication
1994
Pages
711 - 716
Database
ISI
SICI code
0955-0674(1994)6:5<711:TGICC->2.0.ZU;2-I
Abstract
Various structural components of intercellular junctions have recently been found to represent (or be related to) products of tumor-suppress or genes. The tumor-suppressor gene product adenomatous polyposis coil (APC) binds to beta(2)-catenin (homologous to the product of Drosophi la armadillo), which is cytoplasmically associated with the cell adhes ion molecule E-cadherin.