Clinically apparent thyroid nodules occur in about 5 percent of the po
pulation. Because most patients with thyroid nodules present initially
to their primary care physician, family physicians should have a thor
ough understanding of the diagnosis and treatment of thyroid nodules.
The history and physical examination may be helpful in detecting thyro
id nodules but are not useful in predicting malignancy. Furthermore, l
aboratory studies, ultrasonography and nuclear medicine scans do not r
eliably differentiate between benign and malignant thyroid nodules. In
most cases, fine-needle aspiration biopsy can accurately identify mal
ignant thyroid nodules. Fine-needle aspiration biopsy is safe and can
be performed in an office setting.