EFFECT OF INTRAVENOUS FRUCTOSE-1,6-DIPHOSPHATE ON MYOCARDIAL-CONTRACTILITY IN PATIENTS WITH LEFT-VENTRICULAR DYSFUNCTION

Study Objective. To examine the effects of fructose-1,6-diphosphate on myocardial performance using nuclear scintigraphy. Design. Prospectiv e, randomized, single-blind, parallel study. Setting. Urban teaching h ospital clinical research center. Patients. Individuals with New York Heart Association functional class II-III heart failure (mild to moder ate). Interventions. Subjects received either intravenous fructose-1,6 -diphosphate 125 mg/kg or normal saline 1.3 ml/kg every 12 hours over 10 minutes for four consecutive doses. Left ventricular performance wa s assessed by radionuclide ventriculography al baseline and within 60 minutes after the fourth infusion. Vital signs were monitored througho ut the study period. Measurements and Main Results. Fructose-1,6-dipho sphate resulted in a modest 7% increase in left ventricular ejection f raction (p<0.05). Peak ejection rate and peak diastolic filling rate d id not change significantly. There were no changes in blood pressure o r heart rate with either fructose-1,6-diphosphate or placebo. Conclusi ons. Fructose-1,6-diphosphate produces a modest but significant increa se in left ventricular ejection fraction in patients with mild to mode rate heart failure.