MICROSOMAL AND PEROXISOMAL FATTY-ACID OXIDATION IN STREPTOZOTOCIN-DIABETIC RAT-LIVER

Microsomal lauric acid hydroxylation and fatty acid peroxisomal beta-o xidation were studied in hepatic subcellulant preparations from strept ozotocin-induced diabetic and diabetic insulin-treated rats. 2. The li ver microsomes of the streptozotocin diabetic rats displayed a similar activity to hydroxylate lauric acid as the control microsomes. 3. Dia betic insulin treated rats showed lower (omega 1) and omega-lauric aci d hydroxylase activities than diabetic and control rats. 4. Streptozot ocin induced diabetes and diabetic insulin-treated rats exhibited no s ignificant changes on peroxisomal palmitoyl CoA beta-oxidation compare d to the control rats. 5. Both microsomal and peroxisomal fatty acid o xidation responded in a similar way in this model of experimental diab etes. Copyright (C) 1997 Elsevier Science Inc.