CEFADROXIL CONCENTRATIONS IN HUMAN SERUM, GINGIVA, AND MANDIBULAR BONE FOLLOWING A SINGLE ORAL-ADMINISTRATION

Cefadroxil concentrations in human serum, gingiva, and mandibular bone were measured by a paper disk method following a single 500-mg oral d ose. The mean peak concentrations in serum, gingiva, and mandibular bo ne occurred at the identical time, 3 hours, and were 12.92 mug/mL, 6.5 0 mug/g, and 2.67 mug/g, respectively. Mean cefadroxil concentration r atios of gingiva/serum and mandibular bone/serum at the peak time were 0.54 and 0.21, respectively. Mean concentrations in gingiva and mandi bular bone at the peak time exceeded the minimum inhibitory concentrat ions for 90% of clinically isolated strains of a alpha-hemolytic strep tococci.