EFFECT OF AMINOETHYLPYRROLES ON CARRAGEENAN-INDUCED INFLAMMATION AND ON LIPID-PEROXIDATION IN RATS - SOME STRUCTURAL ASPECTS

Nine 3-(2-aminoethyl)pyrrole derivatives were investigated as anti-inf lammatory agents in the carrageenan-induced rat paw oedema model and a s antioxidants in the non-enzymatic lipid peroxidation assay. It was f ound that the derivatives which were substituted with a p-toluenesulph onyl group exhibited considerable anti-inflammatory activity and some also showed antioxidant properties. However, the presence of a p-tolue nesulphonyl group did not invariably lead to activity. A structural fe ature which was essential for both activities was the aminoethyl side chain. Although a relationship between the anti-inflammatory and the a ntioxidant activities was not apparent, the combination of these prope rties could be useful.