BIOCOMPATIBLE DELIVERY SYSTEMS FOR OSTEOINDUCTIVE PROTEINS - IMMOBILIZATION OF L-LYSINE IN MICRO-POROUS HYDROXYAPATITE COATINGS

Authors
SHIRKHANZADEH M LIU GQ
Citation
M. Shirkhanzadeh et Gq. Liu, BIOCOMPATIBLE DELIVERY SYSTEMS FOR OSTEOINDUCTIVE PROTEINS - IMMOBILIZATION OF L-LYSINE IN MICRO-POROUS HYDROXYAPATITE COATINGS, Materials letters, 21(1), 1994, pp. 115-118
Citations number
20
Categorie Soggetti
Material Science","Physics, Applied
Journal title
Materials letters → ACNP
ISSN journal
0167577X
Volume
21
Issue
1
Year of publication
1994
Pages
115 - 118
Database
ISI
SICI code
0167-577X(1994)21:1<115:BDSFOP>2.0.ZU;2-4
Abstract
The absorption and immobilization of L-lysine into electrochemically s ynthesized porous hydroxyapatite coatings is described as a method of fabricating delivery systems for sustained release of osteoinductive p roteins. The nature of interfacial interactions between L-lysine and h ydroxyapatite was investigated by FTIR spectroscopy. The formation of hydrogen bonding between the C=O groups of L-lysine and polar OH group s of hydroxyapatite was shown to be a major factor affecting the chemi cal intermolecular attractions.