ANALYSIS OF TRANSMURAL TREND OF MYOCARDIAL INTEGRATED ULTRASOUND BACKSCATTER FOR DIFFERENTIATION OF HYPERTROPHIC CARDIOMYOPATHY AND VENTRICULAR HYPERTROPHY DUE TO HYPERTENSION
J. Naito et al., ANALYSIS OF TRANSMURAL TREND OF MYOCARDIAL INTEGRATED ULTRASOUND BACKSCATTER FOR DIFFERENTIATION OF HYPERTROPHIC CARDIOMYOPATHY AND VENTRICULAR HYPERTROPHY DUE TO HYPERTENSION, Journal of the American College of Cardiology, 24(2), 1994, pp. 517-524
Objectives. This study was undertaken to differentiate hypertrophic ca
rdiomyopathy from hypertensive hypertrophy using a newly developed M-m
ode format integrated backscatter imaging system capable of calibratin
g myocardial integrated backscatter with the power of Doppler signals
from the blood. Background. Myocardial integrated ultrasound backscatt
er changes in patients with hypertrophic cardiomyopathy; however, it i
s unknown whether ultrasound myocardial tissue characterization may be
useful in differentiating hypertrophic cardiomyopathy from hypertensi
ve hypertrophy. Methods. Calibrated myocardial integrated backscatter
and its transmural gradient were measured in the septum and posterior
wall in 31 normal subjects, 13 patients with hypertensive hypertrophy
and 22 patients with hypertrophic cardiomyopathy. The gradient in inte
grated backscatter was determined as the ratio of calibrated integrate
d backscatter in the endocardial half to that in the epicardial half o
f the myocardium. Results. Cyclic variation of integrated backscatter
was smaller and calibrated myocardial integrated backscatter higher in
patients with hypertrophied hearts than in normal subjects, but there
were no significant differences in either integrated backscatter meas
ure between patients with hypertensive hypertrophy and those with hype
rtrophic cardiomyopathy. Transmural gradient in myocardial integrated
backscatter was present only in patients with hypertrophic cardiomyopa
thy (5.0 +/- 1.8 dB [mean +/- SD] for the septum; 1.2 +/- 1.6 dB for t
he posterior wall). Conclusions. Hypertrophic cardiomyopathy and ventr
icular hypertrophy due to hypertension can be differentiated on the ba
sis of quantitative analysis of the transmural gradient in integrated
backscatter.