A sample of 301 regular amphetamine users was interviewed regarding tr
ansitions between routes of administration of amphetamines. Use of amp
hetamines by injecting was widespread, with two-thirds (67%) of subjec
ts having injected the drug during the preceding 6 months. Needle-shar
ing was common, with 41% of injectors having shared a needle in the mo
nth preceding interview. A transition to regular amphetamine injecting
from other routes of administration was reported by 40% of subjects,
with males being twice as likely to report such a transition. The medi
an number of such transitions was one. The main reasons given by subje
cts for the transition to injecting were liking the ''rush'' from inje
cting, and seeing it as a more economical and a healthier way to use.
A small proportion of subjects (9%) reported a transition away from in
jecting amphetamines, with a median of one such transition. The most c
ommon reason given for abandoning injecting was concern about vascular
damage. Interventions to encourage safer use of amphetamines need to
address the misconceptions that injecting is more economical and more
healthy, and to emphasize the vascular problems associated with inject
ing.