ESTABLISHMENT OF GASTRIC HELICOBACTER-PYLORI INFECTION IN MONGOLIAN GERBILS

An animal model of Helicobacter pylori infection was obtained with Mon golian gerbils. Culture broth of H. pylori ATCC 43504 was orally admin istered to the gerbils. Animals were killed 1, 7, 14, 21, and 42 days after the oral inoculation and the stomachs were excised. Colonization of H. pylori was maintained in the stomachs of all animals throughout the study period of up to 42 days. On microscopic examination after i mmunological and hematoxylin and eosin staining, the organisms were de tected in the mucus layer of the gastric epithelium. All gerbils exhib ited a slowly progressive but typical gastritis, showing superficial e rosion with increasing numbers of infiltrating neutrophils and mononuc lear cells. Forty-two days after the inoculation, lymph follicles were detected in the gastric submucosa. These features are similar to the manifestations of H. pylori infection in humans and, accordingly, this model could be of value for studying H. pylori pathogenicity and for research into agents for the treatment of H. pylori infection in human s.