EFFECT OF CUPROUS ION ON LABELING OF 3 SKELETAL IMAGING AGENTS WITH TC-99M

The effect of increased content of copper on the radiochemical composi tion of three skeletal imaging agents: 99mTC(Sn)-methylene diphosphona te (MDP), Tc-99m(Sn)-pyrophosphate (PYP) and Tc-99m(Sn)-2,3-dicarboxyp ropane-1,1-diphosphonate (DPD) was observed only in the case of Tc-99m (Sn)-MDP. It was found that the radiochemical purity of this radiophar maceutical falls to about 50% when the copper content reaches about 10 (-5) mol dm-3. According to the results of radiochemical and biologica l analyses, it could be concluded that with the increase of copper con tent, the content of free pertechnetate rises, too. The two other radi opharmaceuticals, Tc-99m(Sn)-PYP and Tc-99m(Sn)-DPD, were found to be stable under the given experimental conditions.