A retrospective pilot study of 99 peripheral blood films from 27 patie
nts with burns is reported. Abnormalities of the granular leucocyte se
ries were more common in the more extensive burns and usually preceded
bacteriological evidence of wound pathogens or a clinical decision to
take a blood culture. The evidence suggests that a prospective study
is needed to determine the possible clinical value of reporting such g
ranulocyte abnormalities. Abnormalities of the myelo-monocytic and lym
phocyte cell lines were sufficiently frequent to permit fundamental re
search of possible relevance not only to patients with burns but in ot
her host responses such as in sepsis, malaria or AIDS.