CHANGES IN CORTICAL AND HIPPOCAMPAL EEG ACTIVITY ACCOMPANYING SPONTANEOUS ELECTROCORTICAL SEIZURES IN RATS

The purpose of the present study was to find out whether the occurrenc e of bursts of spontaneous spike-wave discharges (SWD) in rat neocorte x is related to a particular state of vigilance (level of arousal),as some authors suggested, or rather to transitions from one state to ano ther as postulated by others. Patterns of cortical and hippocampal EEG preceding and following the SWD bursts were studied in rats. It has b een found that the beginning of an SWD episode is usually preceded by a shift of cortical activity toward synchronization and replacement of the rhythmic slow activity (RSA) in the hippocampus by large irregula r activity (LIA). After SWD, the cortical activity is usually more des ynchronized and RSA is present more frequently than just before its on set. An analysis of selected episode-free and episode-rich EEG segment s revealed that SWD's occur in abundance at the periods characterized by frequent changes of the hippocampal EEG pattern but are absent duri ng the periods in which long-lasting RSA trains dominate in the record . Thus, the data confirm that SWD occurrence is related more to transi tions from one state to another than to a particular state as such. Th ey also indicate that the preferable conditions for SWD's appear when arousal is decreasing from a moderate to a lower level.