SYNTHESIS OF DOXORUBICIN-CYCLODEXTRIN CONJUGATES

Authors
TANAKA H KOMINATO K YAMAMOTO R YOSHIOKA T NISHIDA H TONE H OKAMOTO R
Citation
H. Tanaka et al., SYNTHESIS OF DOXORUBICIN-CYCLODEXTRIN CONJUGATES, Journal of antibiotics, 47(9), 1994, pp. 1025-1029
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
47
Issue
9
Year of publication
1994
Pages
1025 - 1029
Database
ISI
SICI code
0021-8820(1994)47:9<1025:SODC>2.0.ZU;2-N
Abstract
Doxorubicin-gamma-cyclodextrin conjugates have been synthesized by the coupling of 14-bromodaunomycin with mono half-ester compounds linked to a 6-hydroxyl group of gamma-cyclodextrin. Release of drug from the conjugates in saline phosphate buffer solution and in vitro antitumor activity against L1210 leukemia cells were also investigated.