STAUROSPORINE AGLYCONE (K252-C) AND ARCYRIAFLAVIN-A FROM THE MARINE ASCIDIAN, EUDISTOMA SP

Authors
HORTON PA LONGLEY RE MCCONNELL OJ BALLAS LM
Citation
Pa. Horton et al., STAUROSPORINE AGLYCONE (K252-C) AND ARCYRIAFLAVIN-A FROM THE MARINE ASCIDIAN, EUDISTOMA SP, Experientia, 50(9), 1994, pp. 843-845
Citations number
27
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Experientia → ACNP
ISSN journal
00144754
Volume
50
Issue
9
Year of publication
1994
Pages
843 - 845
Database
ISI
SICI code
0014-4754(1994)50:9<843:SA(AAF>2.0.ZU;2-Z
Abstract
Staurosporine aglycone (K252-c) (compound 1) and arcyriaflavin A (2) w ere isolated from a specimen of the marine ascidian, Eudistoma sp., co llected off the coast of West Africa. In addition to expressing microm olar and submicromolar inhibition of enzyme activity against seven pro tein kinase C isoenzymes and inhibition of proliferation of the human lung cancer A549 and P388 murine leukemia cell lines, 1 also inhibited cell adhesion of the EL-4.IL-2 cell line and expressed activity in th e K562 bleb and neutrophil assays.