EFFECTS OF A YEAST-BASED DIETARY SUPPLEMENTATION ON PREMENSTRUAL-SYNDROME - A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY

A dietary approach has proven to be effective in alleviating symptoms of premenstrual syndrome. In our previous studies, magnesium improved premenstrual irritability and mood scoings. In this double-blind, plac ebo-controlled study, we evaluated the effects of a new dietetic prepa ration (Sillix Donna(R), Giuliani) in 40 patients affected by mild to moderate premenstrual syndrome. Premenstrual symptoms were scored in b oth follicular and luteal phases, at baseline, at 2nd, 4th and 6th mon th of treatment by using the Menstrual Distress Questionnaire (MDQ). T wenty patients were randomised to receive the active preparation and 2 0 placebo. MDQ scores at baseline were similar in the two groups. Five patients of the placebo group dropped out because of treatment failur e. No side effects were observed. Both treatments reduced symptoms alr eady in the 2nd month, but the active preparation was more effective a t all time controls (p < 0.05); at the 6th month it significantly redu ced premenstrual MDQ scores to 18% of baseline values, placebo only to 73%. These data demonstrate that Sillix Donna is effective in reducin g premenstrual distress.