PIRAZOLAC

Pirazoloc, a nonsteroidal anti-inflammatory drug, is a pyrazole-acetic acid derived from indomethacin. The abnormal activity of neutrophils from patients with rheumatoid arthritis was partially corrected with p irazolac. In healthy volunteers, pirazolac caused less faecal blood lo ss than diclofenac, but more than placebo. Pirazolac was at least as e ffective as sulindac in the treatment of patients with rheumatoid arth ritis. Patients with ankylosing spondylitis benefited similarly from t reatment with pirazolac and indomethacin. Pirazolac had similar tolera bility to sulindac, but the withdrawal rate because of intolerable adv erse events was greater in pirazolac recipients versus indomethacin.