The defensive organization of Melancholia was explored with a tachisto
scopic percept-genetic technique, the Defense Mechanism Test. A sample
of 20 women inpatients with a DSM-III-R diagnosis of Major Depressive
Episode or Major Depression, Melancholic Type was contrasted with a m
atched group of depressed outpatients and a matched group of nonclinic
al subjects. Signs of introaggression on the hero, statue-repression,
and stereotype significantly characterized melancholic patients. The l
atter were discriminated from depressed outpatients as showing more si
gns of stereotypy and of discontinuity. Mask-disguise defenses were ty
pically endorsed by Bipolar melancholic patients and significantly dif
ferentiated them from Unipolar melancholic patients. One type of stere
otype (regarding wrong age attributes of the central figure) successfu
lly predicted a poor response to antidepressive therapy. Relevant modi
fications of the current Defense Mechanism Test coding criteria for st
ereotypy are proposed.