The authors describe the appearance of rheumatoid nodules during cyclo
sporin A (CsA) therapy for RA. Their course was evaluated by sonograph
y that revealed an increase in number and size of rheumatoid nodules.
The relationship between CsA treatment and the onset of nodulosis is n
ot clear and further studies are needed to assess the role of CsA trea
tment in the extra-articular manifestations of rheumatoid arthritis su
ch as rheumatoid nodules.