We report a 34-year-old woman with intrathyroid metastasis of chorioca
rcinoma associated with pulmonary and brain metastasis. The patient pr
esented with a solitary thyroid nodule. Needle biopsy showed anaplasti
c malignant cells. Pathologic evaluation after thyroidectomy showed ch
oriocarcinoma in the thyroid gland and the patient subsequently underw
ent combined chemotherapy and radiotherapy with satisfactory response.
This is only the third reported case of metastatic choriocarcinoma in
the thyroid gland and emphasizes this rare clinical presentation of c
horiocarcinoma.