INCLUSION COMPLEXES OF THE NATURAL PRODUCT GOSSYPOL - RECOGNITION BY GOSSYPOL OF HALOGENO METHANES - STRUCTURE OF THE DICHLOROMETHANE COMPLEX OF GOSSYPOL AND SINGLE-CRYSTAL CONSERVATION AFTER DECOMPOSITION

The structures of gossypol complexes are extremely sensitive to the ha logenomethane present as the guest; e.g. changing the number of Cl ato ms in chloromethane derivatives changes the structure of the gossypol complex. The crystals of C30H30O8.CH2Cl2 are monoclinic, space group C 2/c, a = 21.320(4), b = 19.199(6), c = 15.765(2) angstrom, beta = 113. 05(2)-degrees, V = 5916(2) angstrom3, Z = 8, D(x) = 1.35 g/cm3, T = 29 5 K. The structure has been solved by direct methods and refined to th e final R value of 0.084 for 1828 reflections. In the structure H-bond ed gossypol molecules form colums, generating channels in the structur e which are filled by guest molecules. After decomposition (desolvatio n) monocrystals of the complexes are conserved without destruction, in which there are rather wide and empty channels though slightly smalle r than in the complex. An attempt is made to explain some peculiaritie s of the behavior of the gossypol polymorph formed on the basis of its structure with empty channels.