Adequate venous access is an essential component of therapeutic plasma
exchange (TPEX). The simplest kind of venous access is venipuncture o
f antecubital veins, but this technique may be limited by venous size
or scarring following the procedure, requiring the placement of a spec
ialized vascular access device (VAD). VADs provide reliable central ve
nous access and may remain in place for several weeks or months, depen
ding on the VAD and the venous site chosen. Their use, however, is pot
entially limited by the risk of complications. We discuss indications
for insertion, choice of catheter and access site, and complications o
f VAD placement for TPEX.